NGS & AI Embryo Selection: The Revolution in IVF Embryology
How Next-Generation Sequencing detects chromosomal abnormalities and how AI algorithms identify the healthiest embryo—explained for patients without a science degree.
Two technologies are fundamentally changing IVF outcomes in 2026: Next-Generation Sequencing (NGS) for preimplantation genetic testing, and Artificial Intelligence–powered embryo selection algorithms. At Meva Clinic Cyprus, these modern technologies are part of our IVF Cyprus Special program for couples undergoing fertility treatment.
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What Is NGS and Why Does It Matter?
Next-Generation Sequencing is a high-throughput DNA analysis technology that screens all 23 pairs of chromosomes in a single biopsy sample taken from a Day-5 blastocyst. Unlike older FISH-based testing (which screened only 5–9 chromosomes), NGS provides complete chromosomal coverage. Chromosomally abnormal embryos—called aneuploid embryos—account for 50–70% of all IVF failures and early miscarriages. By transferring only euploid (chromosomally normal) embryos, NGS-guided PGT-A (Preimplantation Genetic Testing for Aneuploidies) reduces miscarriage rates by up to 73% and improves single-embryo transfer success rates to 65–70% per transfer.
Key Terms Simply Explained
Aneuploidy: An embryo with the wrong number of chromosomes (e.g., Down syndrome arises from an extra chromosome 21). Blastocyst: A Day-5 embryo—the optimal developmental stage for biopsy and transfer. Euploid embryo: A chromosomally normal embryo with the highest implantation potential. PGT-A: The clinical test using NGS to screen embryos for aneuploidies before transfer.
AI-Powered Embryo Selection: iDAScore & EVA®
Meva Clinic Cyprus uses time-lapse incubators (Miri® by Esco Medical) that photograph embryos every 10 minutes throughout development. Our AI platform—trained on over 1.2 million embryo images—analyses 70+ morphokinetic parameters (timing of cell divisions, symmetry, fragmentation patterns) to assign each embryo a viability score. In a prospective study of 1,800 transfers, AI-selected embryos achieved a 12% higher live-birth rate compared to traditional morphology selection alone.
Frequently Asked Questions
Do I need NGS/PGT-A for every IVF cycle?+
Does the biopsy harm the embryo?+
How long does NGS testing take?+
What is the cost of PGT-A at Meva Clinic Cyprus?+
Can AI replace the embryologist?+
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