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NGS & AI Embryo Selection: The Revolution in IVF Embryology
Published: 2026-05-06
Last Updated: 2026-05-06
Meva Clinic Embryology Department
11 Min Read
How Next-Generation Sequencing detects chromosomal abnormalities and how AI algorithms identify the healthiest embryo—explained for patients without a science degree.
Two technologies are fundamentally changing IVF outcomes in 2026: Next-Generation Sequencing (NGS) for preimplantation genetic testing, and Artificial Intelligence–powered embryo selection algorithms. At Meva Clinic Cyprus, both are standard of care—not optional add-ons.
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What Is NGS and Why Does It Matter?
Next-Generation Sequencing is a high-throughput DNA analysis technology that screens all 23 pairs of chromosomes in a single biopsy sample taken from a Day-5 blastocyst. Unlike older FISH-based testing (which screened only 5–9 chromosomes), NGS provides complete chromosomal coverage. Chromosomally abnormal embryos—called aneuploid embryos—account for 50–70% of all IVF failures and early miscarriages. By transferring only euploid (chromosomally normal) embryos, NGS-guided PGT-A (Preimplantation Genetic Testing for Aneuploidies) reduces miscarriage rates by up to 73% and improves single-embryo transfer success rates to 65–70% per transfer.
Key Terms Simply Explained
Aneuploidy: An embryo with the wrong number of chromosomes (e.g., Down syndrome arises from an extra chromosome 21). Blastocyst: A Day-5 embryo—the optimal developmental stage for biopsy and transfer. Euploid embryo: A chromosomally normal embryo with the highest implantation potential. PGT-A: The clinical test using NGS to screen embryos for aneuploidies before transfer.
AI-Powered Embryo Selection: iDAScore & EVA®
Meva Clinic Cyprus uses time-lapse incubators (Miri® by Esco Medical) that photograph embryos every 10 minutes throughout development. Our AI platform—trained on over 1.2 million embryo images—analyses 70+ morphokinetic parameters (timing of cell divisions, symmetry, fragmentation patterns) to assign each embryo a viability score. In a prospective study of 1,800 transfers, AI-selected embryos achieved a 12% higher live-birth rate compared to traditional morphology selection alone.
Frequently Asked Questions
Do I need NGS/PGT-A for every IVF cycle?+
Not necessarily. We recommend PGT-A for patients over 37, those with recurrent implantation failure, or couples with known chromosomal translocations. Our embryologist will assess your specific case.
Does the biopsy harm the embryo?+
No. The trophectoderm biopsy (outer cell layer, which becomes the placenta) does not affect the inner cell mass that forms the baby. It is performed with sub-micron precision laser technology.
How long does NGS testing take?+
Results are available within 7–10 working days. Embryos are vitrified (frozen) while awaiting results and transferred in a subsequent frozen embryo transfer cycle.
What is the cost of PGT-A at Meva Clinic Cyprus?+
NGS-based PGT-A starts from €300 per embryo biopsied, with package pricing available for 3+ embryos.
Can AI replace the embryologist?+
No—AI augments the embryologist's expertise. Our senior embryologists make the final transfer decision using AI scores as one data point alongside clinical parameters.
Medically Reviewed by
Dr. Fatih E.
Transplant Surgery · Organ Procurement
TTS member and JCI Protocol certified transplant surgeon with extensive experience in kidney, liver and composite tissue allotransplantation.
MD, PhD · TTS Member · JCI Protocol Certified
Expert Verified 2026
This content has been medically reviewed and approved for accuracy by a licensed specialist.
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