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Ovarian PRP: Scientific Facts for Low AMH & Poor Reserve Patients
Published: 2026-05-08
Last Updated: 2026-05-08
Dr. Harun A.
10 Min Read
How platelet-rich plasma (PRP) and stem cell therapies rejuvenate ovarian tissue at the cellular level. Who qualifies, and what results to expect.
Diminished ovarian reserve (DOR), characterised by a low antral follicle count (AFC) and reduced Anti-Müllerian hormone (AMH), affects approximately 10% of women seeking fertility treatment. Conventional IVF protocols often yield poor results in this group. Platelet-Rich Plasma (PRP) ovarian rejuvenation—pioneered in Greece and now offered at Meva Clinic Cyprus—represents a scientifically substantiated adjuvant therapy that may restore follicular activity in previously non-responsive ovaries.
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The Cellular Mechanism of PRP
PRP contains concentrated growth factors (PDGF, TGF-β, VEGF, IGF-1) derived from the patient's own blood. When injected directly into the ovarian cortex under ultrasound guidance, these factors stimulate granulosa cell proliferation, improve local vascularisation, and may activate dormant primordial follicles. A 2022 landmark study (Sfakianoudis et al., J Clin Med) demonstrated AMH increases of 35–120% at 3-month follow-up in a cohort of 60 poor-responder patients.
Who Is a Candidate?
PRP is indicated for patients with: AMH < 0.5 ng/mL; AFC < 4; two or more failed IVF cycles due to poor response; premature ovarian insufficiency (POI) before natural menopause. It is contraindicated in active ovarian malignancy, platelet disorders, or ongoing anticoagulant therapy.
The Meva Protocol — Clinical Case Tone
A 39-year-old patient from Bucharest arrived at Meva Clinic Cyprus with AMH 0.18 ng/mL and AFC of 2 following two failed IVF cycles in Romania. Post-PRP (two sessions, 6 weeks apart), her AMH rose to 0.61 ng/mL and AFC to 5. A subsequent stimulated IVF cycle yielded 3 mature oocytes and resulted in a successful blastocyst transfer. This outcome, while not guaranteed, reflects the potential of PRP in appropriately selected patients.
Frequently Asked Questions
How is ovarian PRP performed?+
Under light sedation, a thin needle guided by transvaginal ultrasound delivers 3–5 mL of activated PRP into each ovary. The procedure takes approximately 20 minutes.
How soon can I start IVF after PRP?+
We recommend waiting 6–8 weeks post-injection before commencing ovarian stimulation, allowing time for follicular activation.
What is the cost of ovarian PRP at Meva Clinic?+
Our PRP rejuvenation package starts from €800 per session, often combined with our IVF protocol for a bundled rate.
Is PRP evidence-based?+
Multiple peer-reviewed studies support PRP's efficacy in poor responders. However, it is not a guaranteed treatment; response rates vary by individual baseline ovarian biology.
Can stem cells be combined with PRP?+
Yes. Our advanced protocol combines PRP with autologous stem cell infusion for patients with severe POI, offering potentially greater regenerative potential.
Medically Reviewed by
Dr. Fatih E.
Transplant Surgery · Organ Procurement
TTS member and JCI Protocol certified transplant surgeon with extensive experience in kidney, liver and composite tissue allotransplantation.
MD, PhD · TTS Member · JCI Protocol Certified
Expert Verified 2026
This content has been medically reviewed and approved for accuracy by a licensed specialist.
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