An objective medical review of autologous intraovarian Platelet-Rich Plasma (PRP) for diminished ovarian reserve, examining biological mechanisms, HFEA add-on guidance, and realistic clinical expectations.
Diminished ovarian reserve (DOR) and poor ovarian response (POR) present significant clinical challenges in reproductive medicine. Intraovarian infusion of autologous Platelet-Rich Plasma (PRP) is an investigational adjunctive procedure evaluated for its potential to deliver platelet-derived growth factors (such as VEGF, PDGF, and TGF-β) to the ovarian cortex. Meva Clinic facilitates diagnostic workups in Istanbul and coordinates treatment pathways with specialized partner reproductive teams in Northern Cyprus. Learn more on our IVF Cyprus Special Program.
Clinical Assessment
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Share your treatment question with our international patient team. Suitability and treatment decisions are confirmed by the responsible licensed physician after clinical assessment.
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Prepared through centrifugation of the patient's peripheral blood, autologous PRP contains concentrated platelets and bioactive growth factors. When delivered into ovarian tissue via ultrasound-guided transvaginal injection, these proteins are investigated for their role in promoting local microvascular angiogenesis, attenuating oxidative stress, and signaling dormant primordial follicles.
Regulatory Perspective: HFEA Red Rating and Evidence Status
In its official treatment add-on guidance, the UK Human Fertilisation and Embryology Authority (HFEA) rates intraovarian PRP as RED for improving the chance of having a baby in patients with poor or diminished ovarian reserve. The HFEA indicates that there is currently no high-quality randomized controlled trial (RCT) evidence showing that ovarian PRP is effective at improving live-birth outcomes. While investigational studies explore temporary biomarker changes, PRP is classified as an experimental add-on: it does not create new oocytes, cannot reverse ovarian biological aging, and does not guarantee pregnancy.
Patient Selection and Clinical Monitoring
Ovarian PRP is typically evaluated for patients with diminished ovarian reserve or prior poor stimulation response following detailed consultation with a fertility specialist. Post-procedure monitoring involves scheduled hormonal assessments and antral follicle evaluations according to the individualized clinical protocol.
Frequently Asked Questions
Does ovarian PRP guarantee an increase in AMH levels?↓
No. While some exploratory studies report transient hormonal variations in select patients, biological response varies widely and improved AMH levels are not guaranteed.
Can ovarian PRP create new oocytes?↓
No. Women are born with a finite pool of primordial follicles. PRP is studied for potential influence on existing dormant follicles, not the creation of new eggs.
Clinical Assessment
Would you like a confidential medical review?
Share your treatment question with our international patient team. Suitability and treatment decisions are confirmed by the responsible licensed physician after clinical assessment.
Please do not send sensitive medical documents in your first message. Our team will explain the secure next step.
This content is maintained by Meva Clinic’s Clinical Care Team for patient guidance and clinical transparency. Final treatment suitability, operating physician assignment, surgical planning, and medical decisions are confirmed only after medical history review, in-person consultation, diagnostic tests, anesthesia evaluation, and doctor availability.
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